Abstract
Recently, FXIIa was highlighted as an original attractive target for the development of new anticoagulant drugs with low rates of therapy-related hemorrhages. In this work, we describe the development of a new series of 3-carboxamide-coumarins that are the first potent and selective nonpeptidic inhibitors of FXIIa.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis*
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Amides / chemistry
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Anticoagulants / chemical synthesis*
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Anticoagulants / chemistry
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Coumarins / chemical synthesis*
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Coumarins / chemistry
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Factor XIIa / antagonists & inhibitors*
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Factor XIIa / chemistry
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Structure-Activity Relationship
Substances
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Amides
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Anticoagulants
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Coumarins
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Factor XIIa